No updates recently but I only noticed it not running when I upgraded to version 4 at the end of last year. Uninstalled it and reinstalled it then and today again and I have the same problem. I didn't use it very often so it could've stopped working after an update and I didn't know so super hard to diagnose sadly.
You might try googling the error. It came up with something about windows system files corruption.
I also searched PTC tech support and didn't find the error at all. It may not be directly related to Creo, it may be a system problem that Creo is trying to access.
Thanks! A lot of these were things in the suggested problems as well when I googled. So I made sure to update anything that wasn't current etc.
It ended up being none of the errors I found. I randomly chose the reconfigure option this morning after nothing else worked and that ended up doing the trick. Go figure!
