When constraining parts, two inserts will not fully constrain the part although it is shown as fully constrained.
The part is yellowed as fully constrainted. The box does not say to allow assumptions. I have had parts flip on me do to them not being fully constrained.
If you add an orient constraint, then the part has all its degrees of freedom constrained.
Please correct by either adding allowing assumptions similar to screws or by not showing it as fully constrained.
Edited - 11/14 @1:50pm
Without the align, there are three other options that meet the same criteria for the two insert mates. The "flipping" isn't garaunteed to not happen after you have saved and reopened. I have see that with other files.
I have also noted since this was first requested that the second insert defaults to oriented versus coincident even if the two inserts are perpendicular like the tube and the bolt hole in the tube. It, the software, must be logically programmed that the first insert is a bolt hole and the second insert is a secondary bolt hole for alighment and therefor shouldn't be coincident.