If the user forgets to save his or her work for too long (15 minutes or more) Creo could show a pop up suggestion for the user to do so. This could be non configurable or user configurable to different durations ("only prompt after 45 minutes"for example).
While many Creo users are seasoned professionals, we are all human and sometimes for reasons that seem inexplicable we just forget to save, then comes a fatal error and we lose all that work. From personal experience this has cost me anywhere from 2 to 6 hours this year alone. Maybe a save reminder could help.