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Some time I can just fix it by restart my computer.
This error code is related to (running more than one) anti-virus product on your PC.
Success!Luc
Does it mean my mathcad file has virus?
Not necessarily.
You should search on the internet for 0x80004004 and see what you find,
I wonder how it is related to Mathcad.
The only information we can see is "Microsoft Visual Basic" in the dialog title and a very basic E_ABORT error code.
At what point do you get this error?
In System Properties, Advanced, Environment Variables, System variables, set PATH:
"C:\Program Files (x86)\Microsoft Visual Studio\2019\Enterprise\MSBuild\Current\Bin\MSBuild.
See if that helps.
