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Have just used it on a Dell M6600 Win 7 O/S 64 bit. (Creo Elements/Pro5.0 m130 with WindChill 9.1 m060)
Found it quite useful in finding and performing pertinent registry tweaks. I did not benchmark the laptop before/after so I can't speak to measurable performance gains, however IMHO it can't do anything but help.
We are currently trying to push out the WCI through SCCM. If I can remember, I will post more about our success/failure.
It is a good program overall. I like the export to XLS. Very nice.