Unfortunately I don't have any shareable documentation but a couple things to consider is if you want to use separate ORG containers or just ORG principals. Also, the Enumeration object types at least in Windchill 8.0 could not be customized for each individual ORG so we ended up having to create our own Enumeration object that could be ORG specific. I think the main considerations deal with if the users from different ORGs are allowed to see the data and or user data of the other ORGs.