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I have been using a Mac for a couple years now and have not experienced any major problems accessing Windchill (version 8 or 9.1). There are some minor annoyances, for example with the display of some applets, but I have not found any "show- stopper" issues.
I use Mac OS X almost exclusively. Once in a while, if I have to, I will fire up Windows XP in a VM image. There are some applications in the PTC tool suite that don't run under OS X, like ProductView and Arbortext, so I use a VM for that. But for software development and general high level system architecture type tasks, which is where I tend to spend most of my time these days, I can stay in the Mac world.