We use Sharepoint to give outside vendors access to documents and drawings they require. From my experience, I don't see how Sharepoint could manage Pro/E data.
I am not a Sharepoint expert by any means, but I would consider another application to manage something as important as your CAD Data. Sharepoint was designed for collaboration between users from different locations with a focus on Word Documents, Excel, Powerpoint, etc. It was not intended to manage something as complicated as CAD Data Dependencies.
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