The problem description, platform and maintenance release matches the issue described in this PTC doc.
PDMLink 10.1 M030 Windows Server 2008 R2 Standard
Creo 2.0 M100
problem is sometime intermittent , sometimes easy to replicate.
Seen in the Creo embedded browser.
Since you just don't casually install Maintenance releases, and the document was lacking any additional mitigation strategies, I asked PTC Support to provide info on 1.) how to confirm this is the issue and 2.) how to workaround. I am awaiting their promised response.......
In the meantime, I wanted to see if anyone had already run into this and received any helpful info from PTC or any other source. I have attached the error.