Venting time, why is PDF export still so terrible? Even using a pentable (the work around for the last few years since it has been broken) with the pens sizes turned down to pretty much zero the drawings are aweful. Is it too much to expect for this to work? 
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Remove those entries from the config.pro and make a file named
table.pnt
Add the following to the file: make sure the file does not have a hidden .txt extension
pen 1 thickness .002 in
pen 2 thickness .002 in
pen 3 thickness .002 in
pen 4 thickness .002 in
pen 5 thickness .002 in
pen 6 thickness .002 in
pen 7 thickness .002 in
pen 8 thickness .002 in
Place the file in your working directory (folder).
Use the export to PDF dialog and check the Use Pen Table option in the option dialog.
Now export the PDF.
This worked for me on this file using 600-PDI setting:
That is a 1/8" ball at 1:1 on an A-size drawing zoomed 800% in Adobe reader.
EDIT: I only suggest you try this method 1st to make sure you can get the output you want. After that, follow the steps of the other replies to integrate the settings into your default configuration.
