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As with several others, I could not get KEPWare to autogenerate ODBC tags for my MariaDB. The system could see the table in the database but would fail generation.
The problem was that even though the DSN was properly configured with the username and password for the database, KEPWare was not bringing them into the Channel Definition. As soon as I updated the field in it, the problem cleared up and tags started generating correctly.
Same issue - "Can't generate tag from Microsoft SQL database": https://community.ptc.com/t5/Mfg-Solutions-Apps/Can-t-generate-tag-from-Microsoft-SQL-database/td-p/588079