I haven't spent a lot of time in Creo 3 yet, but I've played with it and here are somethings you'll need to know.
The right mouse menu in Creo 3 is populated with icons, in Creo 2 it's all text. Make sure you know the names of the commands.
In Creo 3 hen you switch from one window to another, it's automatically "activated", in Creo 2 you have to manually activate the window when you switch using the green check mark button on the view tab. You can set Creo 3 to act like Creo 2 by setting the config option activate_window-automatically to no.
I believe Creo 3 has more commands in the "Quick launch" toolbar at the top of the screen by default. Specifically, some of the window tools (close, activate, switch windows, etc.) are there and I believe these are not by default in Creo 2.
There is no "notification center" in Creo 2.
For the most part, however, they are very similar.
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