I wanted to Run multiple simulation at a time, i need a help how the studies models will be set in order to Run
This forum is for Creo Simulation Live, not for Creo Simulate. I think you'll get better responses by posting in the Simulate forum: https://community.ptc.com/t5/Simulation/bd-p/simulation
Have you read the documentation?
Do you mean multiple solvers running at same time or multiple sequential analysis, only one at a time, but automatic sequence?
No set difference, the study model is the same/identical whether doing RUN -start, or Run - batch, or Run Distributed Batch.