How long have you been using Pro/E on this workstation? If this is a new workstation with a new installation of Pro/E or Creo, perhaps the install was incomplete. I'd suggest checking for updated drivers for your mouse and graphics card. I'd also check to make sure your graphics card is supported by PTC for your specific version of Creo or Pro/E. If you call customer support, that's one of the first things they'll try to determine.
After the drivers are confirmed to be updated, try re-installing Pro/E again. Let us know if the problem recurs. If you changed the graphics card and the problem went away, this sounds like a graphics issue. You may try turning on software graphics as a temporary fix? Go into your config.pro file (or Tools>Options) and set the following option:
Usually this is set to opengl but it's well-known that sometimes graphics issues can be resolved (or at least narrowed down) by trying this option.
Let us know if any of these suggestions worked for you.