rmyers! Thank you so much for taking the time to write this. I just updated to Windows 10 finally and my mouse stopped scrolling in Creo! This very old post saved my bacon. Thank you for the pictures and great description.
I have found solutions for Windows 10 in this post, but how do I get Windows 7 with Creo4.0 to work with my mouse? I have no functionality for panning, zooming or rotating.
I'm having this same problem with my wireless M590 and the above solutions did not work but I have the other culprit to my problem which solved it and though I would share:
If you are having trouble zooming in Creo with mouse wheel go to control panel>hardware sound>mouse and click on the "Wheel" tab and set the option in the vertical scrolling area "one screen at a time" this solved my problem.