Trend Micro or other Virus software causing problems with Windchill and Creo?

Since mid-January we have seen a host of issues related to Trend Micro, most common is a "Page not displayed" error within Creo's embedded browser. (Chrome or IE, does't matter). Other problems occur when we do a general process within the embedded browser, such as check ins, add to workspace, and update our of date revisions.  We've also had Creo crash and hang at random times and Trend always shows as the most active process, and twice had Trend quarantine both Creo and the Workgroup manager. 

We have done a number of exceptions in Trend, but any given Trend update seems to unlearn and require relearning (if you will) to allow Creo and its embedded browser to function.

Anyone else experiencing this or anything like it?