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It should be supported by the PTC Integrity Modeler to connect to a Cluster SQL-Server DB. In Version 9.2 it is only a local DB supported.
-> Opended Enhancement Request: https://community.ptc.com/t5/Integrity-Windchill-Systems/Connecting-a-Cluster-DB-to-the-PTC-Integrity-Modeler-should-be/idi-p/657710