Large assembly management is a never ending process. In this post https://community.ptc.com/t5/3D-Part-Assembly-Design/Large-Assembly-Training/m-p/728764 there is a PDF that will help explain some of the aspects of it.
Simplified reps are your main tool. You will have to meticulously maintain your working reps. Make sure you aren't opening your master rep ever (unless absolutely needed).
There is no one configuration option that makes large assemblies perform better, there are some settings that may help tho. This is my list, but it is in addition to our standard config.pro setting so there may be more settings that are helpful and not included in my list. I tried to include "reasons" for my setting choice, which may help you decide if you want to use that setting or not.
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OPTION
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VALUE
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REASON
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allow_freeze_failed_assy_comp
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yes
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REQUIRED
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atb_auto_check_on_retrieve
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off
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this should be off, it is on by default
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auto_place_max_number
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1
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this has to do with auto placement of interface components and can slow down assy of hardware with interface enabled
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auto_regen_views
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no
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REQUIRED - you must manually regen sheets/views, otherwise it causes significant delays
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autoplace_single_comp
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no
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Autoplace interface components can significantly slow assy times
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check_interference_of_matches
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no
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it is possible this option can slow assy times when set to yes (default it yes)
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comp_assemble_with_interface
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none
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comp assy is an interface option that may significantly slow assy times
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create_temp_interfaces
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no
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temporary interfaces can significantly impact assy performance
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enable_auto_regen
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no
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enable auto regen Yes (default) has potentially negative large assy effects
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fasthlr
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no
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unknown effects
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interface_quality
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0
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this option when set to anything other than zero can seriously affect print time. It is really for PLOTTING, where a pen would got over and over the same line.
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open_simplified_rep_by_default
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yes
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recommended so you don't accidentally open the master rep on a large assy
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shade_quality
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3
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shade quality is EXTREMELY DETRIMENTAL TO LARGE ASSY PERFORMANCE
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smooth_lines
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no
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unknown effects
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