Also, I dont know why the Text Block, Text Box, Image, Copy, and Paste are greyed out.
Try to left click somewhere in an empty space of your sheet and see if that helps.
But then - if the focus (cursor) really would be in some other region (was my first guess, too) it would be strange if "Area" would NOT be greyed out as we can see in your picture.
I could not duplicate what we see in your picture in Prime 11 (at least not in 11.0.0.0; have not installed the current 11.0.1.1).
Either ALL are active (if the cursor is in an empty space), or all are greyed out (if the cursor is inside a math or text region) or "Area" is greyed out and the others are active (when we are inside an area).
But I could find no situation where Area would be active and the other three are greyed out.
Do you experience this effect right at the start when you create a new worksheet?
Are the keyboard shorts working for creating a text region (Ctrl+T) or a text block (Ctrl+Shift+T)?