I'm using Excel 2016 and it seems to work fine with Mathcad 15 M045.
Keep in mind, however, that this refers to the Excel components and data import into Mathcad. The Mathcad Add-in for MS Excel quit working around Office 2013 (there are many Forum discussions on this issue). Be careful what you read, because there is some confusion between basic integration between Excel and Mathcad versus the Excel Add-in that was created by Mathsoft and is no longer supported by PTC.
That said, I can copy Excel data into Mathcad matrices as well as using the Data Import tool to import data into a Mathcad worksheet with no problems using the latest releases of both Mathcad 15 (M045) and MS Excel (2016).
I also confirm that the versions of Mathcad 15 M045 and MS Excel 2016 (in OS Win 8.1 x64) work together normally.
I found the same issue when my laptop upgrade to Win10.
Open excel 2016 in Mathcad 15.0, the software will be blocked for a long long time, unless you stop the excel in "task manager" .
Who can support me?
Use prime it is better. Mathcad 15 is out of date and is not going to be supported forever
Best laugh I've had in days!
Diehard M15 user, I've not had any problems with opening Excel from MC15_M045; it's probably less than 2 seconds. Are you using HDD or SSD in your computer?