Hi @Janaki.Raman
Applying the inputs directly to the worksheet is not possible, because the worksheet itself does not contain the calculation engine.
That engine is entirely in Mathcad, so you'd need to open the worksheet in it to perform the actual calculation.
In your situation (parallel users), the solution is to open a different worksheet file, but which.
Instead you can consider the original worksheet as a "template" of sorts, based on which you create temporary copies that would be deleted after results are being sent back to ThingWorx. These copies would have a very limited lifetime - seconds. These temporary copies should have as filename a sort of unique identifier: "1233-13232-abacdef-34343OriginalWorksheet.mcdx".
Hope it helps.