For this kind of design ,you should create a master mashup holding a menu widget on the header and a contained mashup below it .You can also add footer and other thing as required in the master mashup.Then create your mashups (for which you will be switching by clicking on menu items) .Select master mashup (which you created above) for these mashups (master mashup is a property for every mashup ) and this way you can achieve required design .So there will be a master mashup for every contained mashup in this design and you can attach your mashups as menu items and also give them some name/icon accordingly .There could be other ways to achieve this, but I have done by this way and it works fine .
Thanks ,
Mukul Narang
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