I was able to get this system to actuate using only the 3D contact connections in Creo Mechanisms (as well as a linear and rotary motor). I did not try the CAM/follower with lift off. The hardest part was pre positioning the chain using the drag tool. Because there are so many pin connections it was tremendously inefficient. I cut a big section out of the chain in hopes of speeding up the process. Anyway the biggest challenge was to "tension" the chain. There is no tool to do effectively other than the drag tool. As you can see the chain tends to wander and kink.
The simulation may have benefited from some gravity physics but I do not have that license. Anyway I was able to functionally simulate it, but as far as analysis wise not sure what I can get out of this. \
I think it may have benefited me to assembly the chain in place in the closed position and then run a kinematic analysis to move the system to the open position. It seems the "run analysis" works better at calculating the position/rotation of all elements better then then the drag tool. Once you are in the end state of the analysis you can capture that as a snapshot and return to that state for further analysis.