The answer depends on what you meant when you said "thingworx".
ThingWorx Platform (the classic ThingWorx that everybody knows) does not have an out of the box connector for Salesforce. I am very sure that many partners though created such a connector.
ThingWorx Flow (the integration platform, which is auxiliary to ThingWorx, and not required by ThingWorx Platform to work) does contain lots of connectors, and also a rather rich Salesforce connector. Details about it are available here: https://support.ptc.com/help/thingworx/platform/r9/en/index.html#page/ThingWorx/Help/Integration_Orchestration/Salesforce/SalesforceConnector.html
If you don't have ThingWorx Flow installed, I would install it, and after that you can build ThingWorx Services, in Composer with the Salesforce connector, in a graphical manner, using Flow's interface integrated very well in the service builder (so you don't need to use two different systems).
Hope it helps.