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@Shaikh_Naushad wrote:

Can I import a pre-designed part file in a Creo Assembly and constraint it with a skeleton? If yes, then how?

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Any existing Creo part can be added to a skeleton driven assy just as you would to any assy. You can use skeleton geometry to constrain the location of the part.

If you want to make this existing part's geometry driven by your new skeleton, that's possible but you'll have to insert a copy geometry feature in the part at the top of the tree and then do a lot of redefining of features to make them dependent on that copy geometry.